His entry to the contest is titled, "A Novel Peptide Alters the Alzheimer’s β-amyloid Equilibrium to Protect Against Aβ Oligomer Neurotoxicity."  In his research, Brian investigated, discovered and characterized a small molecule that could potentially treat Alzheimers Disease through a unique approach involving a naturally produced peptide called β-amyloid (Aβ). In Alzheimers patients, this peptide clumps to form structures called oligomers that are harmful to cells.  The molecule that Brian discovered, SS31, prevents the formation of these harmful oligomers, and has great potential as a therapy for Alzheimer’s disease.

The Siemens Foundation established the Siemens Competition in Math, Science & Technology in 1999. The Competition is the nation’s premiere science research competition for high school students and seeks to promote excellence by encouraging students to undertake individual or team research projects. It fosters intensive research that improves students' understanding of the value of scientific study and informs their consideration of future careers in these disciplines. - From the Siemens Math and Science Competition website.